Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls

Phase 1 Study of the Effects of Systemic Nitric Oxide Inhibition With Ng-Monomethyl-L-Arginine on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00345150

Enrollment

Registered

2006-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2006-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

hypertension, nitric oxide, renal hemodynamics

Brief summary

The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension. The results are compared with a group of healthy subjects.

Detailed description

The study investigates the effects of Ng-monomethyl-L-arginine (L-NMMA) on: 1. renal hemodynamics (renal plasma flow and glomerular filtration rate) 2. renal sodium excretion 3. lithium clearance and fractional lithium excretion 4. plasma levels of vasoactive hormones 5. blood pressure and heart rate

Interventions

DRUGNg-monomethyl-L-arginine (drug)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Essential hypertension (blood pressure \> 140/90) with no signs of secondary hypertension * P-creatinine \< 200 µmol/L

Exclusion criteria

* Anamnestic or clinical signs of heart disease, renal disease, liver disease, neoplastic disease, anemia or cerebro-vascular insult * Medication except antihypertensives * Drug or alcohol abuse * Pregnancy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026