Opioid Dependence
Conditions
Brief summary
A 17 week, double-blind, randomized, parallel group, four arm design outpatient study comparing LAAM, buprenorphine and two dose levels of methadone for the treatment of opioid dependence.
Interventions
DRUGLAAM. buprenorphine and methadone
Sponsors
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
21 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
Inclusion * age 21 to 55 years * diagnosis of opioid dependence by criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) * evidence of recent opioid use on toxicologic screening Exclusion * serious medical or psychiatric illness requiring long-term medication * positive pregnancy test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study retention | — |
| Drug use | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety | — |
Countries
United States
Outcome results
None listed