Cytogenetic Study of Ocular Melanoma

Molecular and Cytogenetic Studies of Ocular Melanoma

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00344799

Enrollment

Registered

2006-06-27

Start date

2005-01-08

Completion date

2020-10-23

Last updated

2021-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Choroidal Melanoma

Keywords

Choroidal Melanoma, Choroidal Malignant Melanoma, Ocular Melanoma, Uveal Melanoma

Brief summary

Patients who are diagnosed with choroidal melanoma and undergo I-125 plaque or enucleation surgery consent to participate in the study. A tumor sample taken during surgery is studied in the lab for genetic features. These features and features of subjects' clinical course are recorded. Analysis of the data may identify genetic features that are indicative of prognostic factors including risk of metastasis.

Detailed description

The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patient with diagnosis of ocular melanoma 2. Patient with local treatment plan for ocular melanoma- plaque brachytherapy or enucleation 3. Patient 18 years of age or older 4. Archival enucleation specimens with diagnosis of ocular melanoma

Exclusion criteria

1. Patient who refuses local melanoma treatment 2. Patient who refuses to participate in this study

Countries

United States

Outcome results