Anemia, Cardiac Surgery, Intensive Care
Conditions
Keywords
anemia, intensive care, cardiac surgery, iron metabolism, hepcidin
Brief summary
Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation.
Detailed description
Anemia in intensive care and post-operative patients is due to both blood loss (leading to iron loss) and inflammation. The latter is known to interfere with iron metabolism, inducing iron storage instead of using it for hemoglobin synthesis. The discover of a new regulatory hormone of iron metabolism, hepcidin, may help us to better understand the link between inflammation and iron functional deficit. The aim of our study is to observe the variation of usual iron metabolism biological markers and of hepcidin, in order to define the better marker of iron loss in these clinical situations.
Interventions
None listed
Sponsors
Société Française d'Anesthésie et de Réanimation
Institut National de la Santé Et de la Recherche Médicale, France
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 88 Years
Healthy volunteers
No
Inclusion criteria
* Anemia (haemoglobin \< 10 g/dL) * Hospitalization in ICU for an expected duration of 7 days or more * Or, day one post cardiac surgery
Exclusion criteria
* Chronic anemia (Hb \< 9 g/dL for more than one month before hospitalization) * Iron metabolism disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional iron deficiency | during the study |
Secondary
| Measure | Time frame |
|---|---|
| fatigue assessed by the MFI20 score for cardiac surgery patients | at one day,at seven days and at 28 days |
Countries
France
Outcome results
None listed