Heart Failure
Conditions
Brief summary
The purpose of this study is to determine whether oxygen therapy during sleep improves quality of life, exercise capacity and heart function among patients with chronic heart failure and central sleep apnea.
Detailed description
Oxygen therapy reduces the number of central apneas among patients with congestive heart failure but it is unknown whether quality of life and heart function also improve. We aim to test whether the quality of life, exercise capacity and heart function are improved with nocturnal oxygen therapy during 6 weeks with nocturnal oxygen from oxygen concentrator or nocturnal air from placebo concentrator.
Interventions
DEVICEnocturnal oxygen treatment from oxygen concentrators
Sponsors
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Stable heart failure with left ventricular dysfunction * Cheyne-Stokes respiration with central AHI\>15 and obstructive AHI\<5
Exclusion criteria
* Heart infarction within 3 months. * Dementia * Chronic obstructive pulmonary disease and daytime hypoxemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exercise capacity | — |
| Quality of life (SF-36, Minnesota, Living with heart failure questionnaire) | — |
| Brain natriuretic peptide (BNP) | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitality anxiety and depression scale | — |
| Epworth sleepiness scale | — |
| Karolinska sleepiness scale | — |
| Routine lab (haemoglobins, thyroid status, creatinin) | — |
| Echocardiography | — |
| Urinary cortisol | — |
| Polysomnography | — |
| Arrhythmias from 24 hour Holter-ECG registration | — |
| Heart rate variability | — |
| Urinary catecholamines | — |
| Radionuclide determination of ejection fraction | — |
| Mortality and hospitalization for cardiovascular causes (combined and individually) | — |
Countries
Sweden
Outcome results
None listed