Clinical Study on Optimised Removal of Protein-bound Uremic Toxins With Convective Dialysis Treatment.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00337831

Enrollment

Registered

2006-06-16

Start date

2006-05-31

Completion date

2007-05-31

Last updated

2011-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Renal Failure

Brief summary

Patients will be treated with hemodiafiltration (HDF) in postdilution mode, as a control therapy, during 9 weeks. During week 5 the 1st intervention treatment, predilution hemofiltration (HF) or predilution HDF, will be performed as a midweek session. After 4 additional weeks of control therapy the other intervention treatment will be performed. Samples will be taken during week 4, 5 and 9: from inlet blood flow (0, 30, 60, 120 and 240 min), from outlet blood flow and dialysate outflow (30, 60, 120 and 240 min).

Interventions

PROCEDUREPerformance of predilution hemofiltration, predilution hemodiafiltration or postdilution hemodiafiltration

Performance of predilution hemofiltration, predilution hemodiafiltration or postdilution hemodiafiltration is followed.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* stable on hemodialysis \>= 6 months * of which presently on high-flux HD \>= 1 month * 18 years \< age \< 85 years * blood flow rate \>= 300ml/min

Exclusion criteria

* expected survival \< 1 year * expected transplant within \< 1 year * infectious diseases * pregnancy * chronic inflammation condition * treated with single needle dialysis * presently treated with hemodiafiltration or low-flux hemodiafiltration * expected intradialytic body weight gain \>= 4kg

Design outcomes

Primary

Measure	Time frame
To evaluate what is more effective for convective removal of protein-bound solutes - predilution or postdilution of blood?	Samples taken at week 4, 5 and 9. Bloodsamples taken at 0, 30, 60, 120 and 240 min. Dialysate taken at 30, 60, 120 and 240 min.
To check which respective roles diffusion and convection play in the removal of protein-bound uremic toxins?	Samples taken at week 4, 5 and 9. Bloodsamples taken at 0, 30, 60, 120 and 240 min. Dialysate taken at 30, 60, 120 and 240 min.

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026