Esophageal Varices, Liver Cirrhosis
Conditions
Brief summary
Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation. Patients with Child B and C cirrhosis with high risk varices and no previous variceal bleeding are randomized to propranolol or variceal bleeding. Primary end point is variceal bleeding
Interventions
PROCEDUREendoscopic variceal banding
DRUGpropranolol
Sponsors
University of Padova
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* liver cirrhosis * child pugh\>=B7 * studied for transplantation * age between 18 an 65 ys * no previous bleeding from varices * signed informed consent
Exclusion criteria
* esophageal varices less than F2 blue * gastric varices * previous variceal surgical or radiological or endoscopical treatment * hepatocarcinoma * portal vein thrombosis * severe heart, respiratory or renal failure * contraindications to betablockers * treatment with nitrates, calcium antagonist or anti-arhythmic drugs that can not be suspended * Pregnancy * neoplasias * non cooperation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| variceal bleeding | — |
Countries
Italy
Outcome results
None listed