Patients With Systemic Inflammatory Diseases Receiving for the First Time a Protracted General Corticostroid Therapy
Conditions
Keywords
Cataracts, Corticosteroids, Scheimpflug, Lens autofluorescence
Brief summary
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.
Detailed description
Corticosteroid therapy is usually regarded as a risk factor for the development of posterior subcapsular cataracts but prospective studies on this topic and accurate assessment of this potential adverse effect are lacking. We will evaluate changes of lens transparency after administration of systemic corticosteroid therapy for at least one year with Scheimpflug photography and quantification of lens autofluorescence.
Interventions
DRUGPrednisolone
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient who starts a treatment with Prednisone, Prednisolone or Methylprednisolone for an Expected time of one year at least, with normal lens autofluorescence at inclusion.
Exclusion criteria
* Previous cataracts and abnormal increase of lens autofluorescence considering age * Previous elevation of intraocular pressure * Progressive inflammatory or non inflammatory ocular disease * Eye drop except artificial tears * Insulin dependent and non insulin dependent diabetes * Atopic dermatitis * Previous protracted corticosteroid therapy * Drugs known to be associated with an increased risk of cataract
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cataracts on Ophthalmologist's Examination | — |
| Increase of Lens Autofluorescence | — |
| Increase of Lens Density on Scheimpflug Photography | — |
Secondary
| Measure | Time frame |
|---|---|
| Potential risk factor of cataracts related to the underlying disease or the individual | — |
| Potential effect of time allowed from the beginning of treatment, duration and dosage of corticosteroids. | — |
Countries
France
Outcome results
None listed