Continuous Regional Analgesia After Total Knee Arthroplasty

Continuous Regional Analgesia After Total Knee Arthroplasty. Normal Saline or Dextrose 5% in Water as Fluid Medium for Pre-Placement Expansion in Order to Facilitate the Catheter Passing

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00337597

Enrollment

Registered

2006-06-16

Start date

2006-05-31

Completion date

2007-12-31

Last updated

2008-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia

Keywords

Normal saline, Dextrose 5% in water, neurostimulation, Continuous regional analgesia after total knee arthroplasty

Brief summary

This prospective, comparative and double blind study is aimed to determine if normal saline or dextrose 5% in water will modify the stimulation during the insertion of the stimulating catheter used for continuous femoral and sciatic blocks in total knee replacement.

Detailed description

The operator is blinded to the medium fluid to expand the perineural femoral and sciatic nerves before threading in the stimulating catheter. He records all the electric data of electrolocation of nerve, which will be compared to determine whether or not a difference in intensity is found between normal saline or dextrose 5% in water.

Interventions

OTHERGlucose 5%

OTHERNaCl 0.9%

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists (ASA) I and II * Male or non-pregnant female * 18 - 80 years of age * Not allergic to iodine or local anesthetics * Absence of abnormality of coagulation * Scheduled for total knee replacement

Design outcomes

Primary

Measure	Time frame
Characteristics of electrolocation of nerve during insertion of the exploring needle and of the stimulating catheter	—

Secondary

Measure	Time frame
Efficacy of post-operative analgesia	during 48 hours

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026