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Adolescent Drug and HIV Prevention in South Africa

Adolescent Drug and HIV Prevention in South Africa

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00336180
Enrollment
7695
Registered
2006-06-13
Start date
2003-09-30
Completion date
2008-04-30
Last updated
2013-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sexually Transmitted Diseases, Substance-Related Disorders

Keywords

Adolescent, Adolescent behavior, Adolescent development, Drinking behavior, Health behavior, Reproductive Behavior, Sexual Behavior, South Africa

Brief summary

The purpose of this trial is to test the effectiveness of a classroom-based prevention program (HealthWise: Learning Life Skills for Young Adults) to reduce the risk of HIV/AIDS and STIs, as well as substance use, among adolescents in one area of South Africa.

Detailed description

Recent estimates of the incidence of HIV among South African youth reveal rates to be among the highest in the world. Research shows that the sexual behaviors that put youth at increased risk for HIV often occur in the context of substance use. Consequently, effective prevention programs will most likely target both types of risk behavior. Research and theory also suggest that a positive youth development approach may be an useful way to reduce risk behavior. Therefore, our study involves the implementation of a classroom-based leisure, life-skill, and sexuality education curriculum, HealthWise: Learning Life Skills for Young Adults. This program is designed to reduce substance use and sexual risk behavior and to increase healthy leisure behavior and intra- and interpersonal skills. Students from 4 high schools are currently receiving the HealthWise lessons in the 8th and 9th grades; students from 5 other schools serve as controls. Participants complete survey assessments on PalmPilots twice per year, until they leave school. Three cohorts of students are participating in this trial. Our hypothesis is that HealthWise participants will engage in less risk behavior than controls. This will be tested using various statistical methodologies, including multiple regression, structural equation modeling, and growth modeling.

Interventions

BEHAVIORALHealthWise South Africa curriculum

18 classroom lessons

Sponsors

National Institute on Drug Abuse (NIDA)
CollaboratorNIH
Penn State University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
Yes

Inclusion criteria

* attending one of nine secondary schools involved in the HealthWise South Africa research trial

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frame
incidence of ATOD use2 years
incidence of lifetime sexual intercourse2 years
rates of condom use2 years
number of sexual partners2 years

Secondary

MeasureTime frame
knowledge and attitudes about substances and sex2 years
healthy leisure attitudes/behaviors2 years
levels of inter- and intrapersonal skills2 years

Countries

South Africa

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026