The Effect of Ischemic Training on Exercise Endurance

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00333905

Enrollment

Registered

2006-06-06

Start date

2006-03-31

Completion date

2008-02-29

Last updated

2009-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease, Congestive Heart Failure, Heart Failure

Keywords

Exercise, Exercise Therapy

Brief summary

The purpose of this study is to determine if reducing blood flow to an exercising muscle during exercise training will enhance the training effect on that muscle in people who have limited exercise because of congestive heart failure

Detailed description

The objective of this study is to determine whether reduction of blood flow during stair-stepping and cycling ergometer leg exercise will contribute to an improvement in whole body exercise capacity or submaximal exercise endurance in patients with mild congestive heart failure. Two groups of 25 patients with mild to moderate CHF, aged 30-70, will be trained for 12 weeks. The experimental group will train with pressure cuffs inflated on one thigh and lower leg during exercise. The cuff will be applied on alternate legs during training, such that each leg has the same duration of ischemic training. The control group will train for a similar duration and intensity without pressure cuffs on the legs. Pre and post training measures will include VO2peak, exercise duration at 30% VO2peak, 6 minute walk test, Minnesota Living with Heart Failure questionnaire

Interventions

PROCEDUREIschemic exercise training

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

30 Years to 71 Years

Healthy volunteers

Inclusion criteria

* Mild Congestive Heart Failure * Must be able to exercise

Exclusion criteria

* Venous or arterial thrombus * Lower extremity arthritis * Blood clotting abnormalities * Claudication * Peripheral vascular disease * Evidence of deep vein thrombosis on ultrasound

Design outcomes

Primary

Measure	Time frame
Exercise duration before and after 12 weeks of training during a submaximal exercise test and distance walked on a 6-minute walk test.	—

Secondary

Measure	Time frame
Peak cycle ergometer VO2max test before and after training	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026