Mechanism of Thrombocytopenia in Infants

Mechanism of Thrombocytopenia in Small for Gestational Age Infants Versus Infants With Maternal Preeclampsia Exposure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00333333

Enrollment

Registered

2006-06-05

Start date

2006-06-30

Completion date

2008-06-30

Last updated

2008-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thrombocytopenia, Small for Gestational Age (SGA), Preeclampsia

Keywords

Thrombocytopenia, Small for Gestational Age (SGA), Preeclampsia

Brief summary

This research project is studying the causes for low platelet levels in preterm infants. Platelets are a component of blood that helps with clotting. The purpose of this study is to determine whether the cause for low platelet levels is the same in infants who are born to mothers with preeclampsia and infants who are small for gestational age.

Detailed description

Thrombocytopenia is a common entity in infants who are born to mothers with preeclampsia and in infants who are small for gestational age. There have been several theories to the mechanism underlying thrombocytopenia in these groups of patients. One mechanism suggests that thrombocytopenia in these populations may be secondary to underproduction of platelets. Other studies have implied that low platelet levels may be due to endothelial activation causing platelet consumption. This study is being performed to help determine the mechanism causing thrombocytopenia in infants born to mothers with preeclampsia and comparing it to the mechanism of thrombocytopenia in infants who are small for gestational age.

Interventions

PROCEDURECord blood

Cord blood will be obtained at the time of delivery.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Infants who are less than 34 weeks gestation * Infants born to mothers with preeclampsia * Infants who are born small for gestational age whose mother did not have preeclampsia

Exclusion criteria

* Infants who are greater than 34 weeks gestation * Infants with known congenital anomalies or known congenital infections

Design outcomes

Primary

Measure	Time frame
To determine the mechanism of thrombocytopenia in small for gestational age infants versus infants with maternal preeclampsia exposure	Each infant will only be enrolled during the time of birth until cord blood is collected.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026