A Methodology Study To Look At Genes In Lung Cells And Tissue From Asthmatic Patients

A Study to Identify a Transcriptomic Profile Indicative of Cycle AMP Pathway Activation in the Lung

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00331292

Enrollment

Registered

2006-05-29

Start date

2006-08-31

Completion date

Unknown

Last updated

2008-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Keywords

Asthma bronchoscopy

Brief summary

The primary goal of this study is to identify a gene or panel of genes which are differentially expressed in lung cells and tissue from asthmatic patients following administration of Ipratropium bromide and eiTher nebulised Albuterol or saline. Each subject in this study will undergo two bronchoscopies.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Have a history of intermittant asthma. * Have asthma symptoms less than once per week. * Have no other significant disease. * Do not take regular oral or inhaled steroids. * Are a non-smoker for the past 12 months with a pack history of less than 5 years.

Exclusion criteria

* Have a history of drug or alcohol abuse. * Have poorly controlled asthma or a history of life-threatening asthma. * Have a history of hypersensitivity to bronchodilators. * Are unable to abstain from inhaled steroids from 14 days prior to the first study visit until completion of the study. * Have received oral steroids within 3 months of study entry. * Have been hospitalized for your asthma within 3 months of study entry. * Have had treatment with an investigational drug within 30 days or 5 half-lives (whichever is longer) preceding the first dose of study medication.

Countries

United States

Outcome results