Alcohol Drinking, Attention Deficit Disorder, Depression, Smoking Cessation
Conditions
Keywords
Alcohol, Bupropion, Chlorzoxazone, Interaction, Induction, Depression, Smoking, Drinking, Cytochrome P450 Enzyme, CYP2B6, CYP2E1, Pharmacogenetics, Pharmacokinetics, Pharmacodynamics, Boston, Tufts University
Brief summary
The two purposes of this study are 1. to determine what effect the chronic and moderate/heavy drinking of alcoholic beverages has 1. on the blood level of bupropion and chlorzoxazone and their major breakdown products in the blood and 2. on the stimulant effect of bupropion and 2. to determine what effect a normal and common (25% frequency) genetic variation of a specific liver enzyme (that breaks down bupropion) has 1. on the blood levels of bupropion and its major breakdown products in the blood and 2. on the stimulant effect of bupropion. Two groups of volunteers will be recruited for this study: 1. volunteers who drink moderate to heavy amounts of alcohol frequently and 2. volunteers who usually do not drink alcohol. Volunteers will NOT be asked to change their drinking (or nondrinking) habits during the study.
Interventions
OTHERTrial Withdrawn 1
Trial Withdrawn 1
OTHERTrial Withdrawn 2
Trial Withdrawn 2
Sponsors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Tufts University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults who are 21 - 55 years of age. * Either 1) Moderate-to-heavy drinkers who drink on average more than 14 but less than 28 drinks per week; OR 2) adults who normally abstain from drinking alcohol.
Exclusion criteria
* Participants who are currently taking prescription medications (including oral contraceptives) * Pregnancy * Body mass index (BMI) greater than 30 * History of seizures or eating disorders
Countries
United States
Outcome results
None listed