Timing of Prophylactic Antibiotics for Cesarean Sections

A Randomized, Double-Blind, Placebo Controlled Trial of Cefazolin Given Either 30 Minutes Prior to Cesarean Section or at Cord Clamping

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00330278

Enrollment

350

Registered

2006-05-26

Start date

2003-01-31

Completion date

2006-01-31

Last updated

2007-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometritis, Wound Infection

Keywords

Cesarean section, Antibiotic prophylaxis, Cefazolin

Brief summary

This is a randomized, double-blinded placebo controlled trial of cefazolin timing before cesarean section fo infection prophylaxis. Subjects are randomized to cefazolin either 30 minutes prior to skin incision or at time of cord-clamping. Primary outcome is infectious morbidity including wound infections and endometritis.

Interventions

DRUGCefazolin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Pregnant 24-43 weeks gestation \> 18 years old Requiring cesarean section -

Exclusion criteria

Receiving antibiotics \< 18 years old Allergy to cefazolin \-

Design outcomes

Primary

Measure	Time frame
Combined infectious morbidity - endometritis + wound infection	—

Secondary

Measure	Time frame
Neonatal sepsis	—
Allergic reactions	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026