Insulin Treatment in Cancer Cachexia

Insulin Treatment in Cancer Cachexia: Effects on Survival, Metabolism and Physical Functioning. A Randomized Prospective Study.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00329615

Enrollment

135

Registered

2006-05-25

Start date

2000-01-31

Completion date

2005-09-30

Last updated

2009-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Cachexia

Keywords

Cancer cachexia, Tumor host metabolism

Brief summary

The study is designed to evaluate whether daily insulin treatment to weight losing cancer patients attenuates progression of cancer cachexia and improves metabolism.

Detailed description

Randomized study with long-term follow-up based on survival, health related quality of life, food intake, resting energy expenditure, body composition, exercise capacity and measurement of metabolic efficiency.

Interventions

DRUGInsulatard, flexpen

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Weight loss * Systemic solid cancer

Exclusion criteria

* Diabetes * Brain metastases * Expectant survival of less than 6 months * Serum creatinine above 200 umol/l * Persistent of recurrent fever * Cholestasis

Design outcomes

Primary

Measure	Time frame
serum tumor markers	—
Health related quality of life,	—
food intake,	—
resting energy expenditure,	—
body composition,	—
metabolic efficiency,	—
spontaneous physical activity,	—
blood and hormonal tests	—

Secondary

Measure	Time frame
Survival	—

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026