Alcoholic Patient, Carcinological Surgery ORL
Conditions
Keywords
Ketamine, Analgesia, Alcool-dependent, carcinological surgery
Brief summary
The principal objective is to evaluate the analgesic effectiveness of the systemic ketamine on the control of the pain (average consumption of morphine at 48 hours) at the alcool-dependent patient, in carcinological surgery ORL. The effect coanalgesic is found for low dose of ketamine and action anti NMDA seems to have a stabilizing effect on this particular type of patient. This imbalance of the receivers, with a greater number of r-NMDA among these patients would involve it a better analgesic effectiveness and less effects dysphoric, to see an improvement on the syndrome of weaning. The secondary objectives evaluate the pain, the ground (dependence with alcohol), the first request analgesic, the tolerance and the signs psychic (syndrome of weaning...) and the satisfaction of the patient.
Detailed description
The principal objective is to evaluate the analgesic effectiveness of the systemic ketamine on the control of the pain (average consumption of morphine at 48 hours) at the alcool-dependent patient, in carcinological surgery ORL. The effect coanalgesic is found for low dose of ketamine and action anti NMDA seems to have a stabilizing effect on this particular type of patient. This imbalance of the receivers, with a greater number of r-NMDA among these patients would involve it a better analgesic effectiveness and less effects dysphoric, to see an improvement on the syndrome of weaning. The secondary objectives evaluate the pain, the ground (dependence with alcohol), the first request analgesic, the tolerance and the signs psychic (syndrome of weaning...) and the satisfaction of the patient.
Interventions
DRUGketamine
Evaluate the analgesic effectiveness of the systemic ketamine on the control of pain in the alcohol-dependent patient
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* patient alcohol-dependent having to undergo a carcinological surgery ORL with tracheotomy or tracheostomy, ASA 1-3
Exclusion criteria
* refusal of the patient * counter-indications with the treatments, * urgency * the specific clinical context (final neoplasy, reanimation) * the treatments for chronic pain containing morphinic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption at 48 hours | at 48 hours |
Secondary
| Measure | Time frame |
|---|---|
| pain | pain |
| the ground (dependence with alcohol) | dependence with alcohol |
| the first request analgesic | the first request analgesic |
| the tolerance and the signs psychic (syndrome of weaning...) | the tolerance and the signs psychic |
| and the satisfaction of the patient | the satisfaction of the patient |
Countries
France
Outcome results
None listed