Breast Cancer
Conditions
Keywords
SNPs, single nucleotide polymorphism, breast atypia, breast epithelial hyperplasia, high risk for breast cancer
Brief summary
A study to examine the potential associations between common single nucleotide polymorphisms and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
Detailed description
A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via random periareolar fine needle aspiration in postmenopausal women at increased risk for breast cancer and taking hormone replacement therapy.
Interventions
PROCEDUREFine needle aspiration
Fine needle aspiration
Sponsors
Intergenetics, Inc.
Carol Fabian, MD
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* postmenopausal women on or off hormone replacement therapy * at high risk of developing breast cancer determined by family or personal history * postmenopausal women not on hormone replacement therapy for at minimum six months prior to corresponding aspiration * willing to participate in companion protocol (KUMC HSC#4601) for random periareolar fine needle aspiration (RPFNA) for correlational studies
Exclusion criteria
* women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane within the six months prior to RPFNA.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of SNP patterns with cytlomorphology of breast fine needle aspirates. | ongoing | develoment of algorithm for prediction of risk of developing breast cancer. |
Countries
United States
Outcome results
None listed