Fissure in Ano, Hemorrhoids
Conditions
Keywords
Galvanic skin response, Anesthesia, Atropine
Brief summary
24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.
Detailed description
Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine. Study hypothesis: SC is not influenced by i.v. administration of atropine.
Interventions
DRUGAdministration of 0,7 mg of atropine
DEVICEMeasurement of skin conductance with Pain detector
Sponsors
Rikshospitalet University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients in ASA-group 1-2 * Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour * informed consent * BMI \<30
Exclusion criteria
* Patients using any medication known to influence the autonomous nervous system * Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect) * BMI \>30 * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of skin conductance fluctuations | — |
Countries
Norway
Contacts
Primary ContactHanne Storm, PhD
Outcome results
None listed