Obesity, Diabetes, Hypertension
Conditions
Keywords
Obesity, Surgery, Gastric bypass, Biliopancreatic diversion with Duodenal switch, Laparoscopy
Brief summary
The purpose of this study is to compare the outcome in a broad perspective after laparoscopic Roux-en-Y gastric bypass and laparoscopic BPD-duodenal switch in the treatment of superobesity (body mass index \[BMI\] \> 50 kg/m2).
Detailed description
Surgery is the only treatment of morbid obesity that has proven to result in efficient and long lasting weight loss. There are few studies comparing different surgical techniques, especially in a randomized setting. Superobesity (BMI \> 50 kg/m2) demands an efficient surgical approach to result in satisfying weight loss. Laparoscopic techniques have been established to perform Roux-en-Y Gastric bypass and Biliopancreatic Diversion with Duodenal Switch which both are good options for treating superobesity. This study aims to compare the outcome after surgery in a broad perspective (weight loss, metabolic normalization, gastro-intestinal side effects, eating patterns, body composition, health economics). Patients will be randomized to either surgical procedure and will be followed for five years.
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* BMI 50-60 kg/m2
Exclusion criteria
* Prior obesity operation * Prior major abdominal surgical procedure * Severe disabling cardiopulmonary disease * Malignancy * Oral steroid treatment * Condition associated with poor compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMI | 5 y |
| Metabolic normalization | 5y |
| Gastro-intestinal side effects | 5y |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life | 5y |
| Health economics | 5y |
| Eating pattern | 5y |
| Vitamin/mineral deficiencies | 5y |
| Body composition | 5y |
Countries
Norway, Sweden