Rheumatoid Arthritis
Conditions
Brief summary
To assess the effects of a 16-week individualized, intensive strength training program in patients with rheumatoid arthritis. Primary and secondary outcomes include: strength and body composition, function, disease activity, pain, quality of life. We hypothesized that improvements would be seen in all of the above outcomes.
Interventions
BEHAVIORALstrength training
Sponsors
Centocor, Inc.
University of Arizona
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Males and females with RA * Over 18 years of age * ACR Functional Class I and II * Taking Remicade \>4 months
Exclusion criteria
* Presence of comorbid conditions contraindicated to exercise, including, but not limited to: 1. heart disease 2. severe osteoporosis: (if \>50 years): T score \< -3.0 for hip or spine excluded; T score \<-2.5 for hip or spine w/o current treatment) 3. (all potential subjects) previous non-traumatic fractures 4. uncontrolled BP * BMI \>40 * Regular use of assistive walking device which would interfere with ability to lift weights * Currently or within the last 3 months participating in aerobic exercise \> 150 minutes a week * Currently or within the last 3 months participating in any regular strength training activities * Presence of neurological impairment that directly limits ability to perform exercise * Participation in concurrent exercise study * Any reason for which the investigator deems it would not be in the patient's best interest to continue in the study * Plans to move away from site within next 1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Strength | — |
| Body Composition | — |
| Function | — |
| Pain | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease Activity | — |
| Fatigue | — |
| Quality of Life | — |
Countries
United States
Outcome results
None listed