Nausea and Vomiting, Postoperative
Conditions
Keywords
postoperative nausea and vomiting PONV antiemetics NK-1 5HT3 casopitant mesylate ZOFRAN ondansetron hydrochloride
Brief summary
This study is being conducted to see if adding GW679769 (casopitant) to ZOFRAN will significantly decrease the number of patients who experience nausea and vomiting after surgery.
Interventions
DRUGGW679769 (casopitant)
Sponsors
GlaxoSmithKline
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* History of PONV and/or motion sickness. * Have not smoked for the last 6 months. * Having certain types of abdominal, breast or shoulder surgeries.
Exclusion criteria
* Pregnant or breastfeeding. * Taking certain medications. * Have certain pre-existing medical conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rates of vomiting and retching | after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Rates of nausea. Blood test results. | after surgery |
Countries
Canada, France, Germany, Hong Kong, Hungary, Ireland, Pakistan, Philippines, Thailand, United Kingdom, United States
Outcome results
None listed