A Neurocognitive Model of Anorexia Nervosa

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00325520

Enrollment

152

Registered

2006-05-15

Start date

2006-05-31

Completion date

2014-05-31

Last updated

2014-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa

Brief summary

The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Detailed description

Patients with Anorexia Nervosa (AN) have extreme difficulty changing their eating behavior, even when they express desire for change. These behaviors seem to override all other potential responses, and can appear perseverative, or habitual. The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

Inclusion: * DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype), current or prior; * Age 16-45; * Inpatient on GCRU * Medically stable. Exclusion: * Any other current major Axis I disorder (including current bulimia nervosa), except major depression; * History of concussion, seizure disorder, or other neurological illness; * History of learning disability; * Acute Suicidality Healthy comparison group: Inclusion: * No current or past psychiatric illness; * Age 16-45 * No history of binge eating or vomiting; * Normal weight (80%-120% ideal body weight) Exclusion: * Significant medical or neurologic illness(concussion, seizure disorder, learning disability, other neurological illness) * Current psychotropic medication or medications known to impact cognition Additional

Exclusion criteria

for fMRI: * Significant Claustrophobia * Pregnancy * Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent metallic ink tattoo * For patients, current psychotropic medications (antidepressants for 2 week (prozac and antipsychotics for 4 weeks) * For patients, any other current Axis I diagnosis

Design outcomes

Primary

Measure	Time frame
Neuropsychological functioning	pre- and post-treatment

Outcome results