Coronary Artery Disease, Obesity
Conditions
Keywords
Obesity, Diets, Heart Disease, Randomized controlled trial, Ischemia.
Brief summary
(1) What effect does behavioral counseling for vegan, for low to moderate fat, and for lowered carbohydrate diets have on coronary blood flow? (2) What are the effects of different diet protocols when caloric intake and exercise are equalized? (3) Do people, so counseled, maintain their modified behaviors after they have completed their diet program? (4) How does targeting different diets affect secondary indices associated with heart disease such as weight, lipid, inflammatory, and thrombotic factors?
Detailed description
Given the current epidemic of overweight and obesity on a global scale (globesity) and the consequent world public health objective of reducing that obesity, it is evident as a practical matter that, the main line of attack must be through diet. The public health objective and the lack of information regarding the long-term public health effects of alternative weight-loss diets motivated this comparative study of the three major types of weight-loss diets and their long term effects on coronary blood flow. Secondary endpoints are inflammatory and other variables associated with heart disease and obesity. Specifically we asked: (1) What effect does behavioral counseling for vegan, for low to moderate fat, and for lowered carbohydrate diets have on coronary blood flow? (2) What are the effects of different diet protocols when caloric intake and exercise are equalized? (3) Do people, so counseled, maintain their modified behaviors after they have completed their diet program? (4) How does targeting different diets affect secondary indices associated with heart disease such as weight, lipid, inflammatory, and thrombotic factors?
Interventions
BEHAVIORALMedium-intensity Minimally-directive Counseling
Sponsors
GM Harrington, PhD
The Camelot Foundation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 59 Years
Healthy volunteers
Yes
Inclusion criteria
BMI greater than 30,
Exclusion criteria
pre-existing co-morbid diseases (documented heart disease, diabetes mellitus, cancer, hypertension, hepatic, renal or gastrointestinal disease), pregnancy or plans for pregnancy. Participants could not be smokers (cigarettes, cigars, pipes or chewing tobacco), take medications (prescription or over the counter medications with the exception of antibiotics), nor take vitamin or mineral supplements. Additionally, they could not currently be on a diet or have been on one during the last 6 months, or have food allergies that would influence food choices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| coronary blood flow | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI | — |
| LDLc | — |
| Total Cholesterol | — |
| HDLc | — |
| Triglycerides | — |
| Homocysteine | — |
| Fibrinogen | — |
| weight | — |
| VLDLc | — |
| TC/HDL | — |
| TG/HDL (Insulin Resistance) | — |
| CRP | — |
| IL-6 | — |
| respiratory quotient | — |
| Lipoprotein (a) | — |
Countries
United States
Outcome results
None listed