Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00324519

Enrollment

Registered

2006-05-11

Start date

2005-02-28

Completion date

2007-04-30

Last updated

2012-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induced Abortion, Pregnancy Trimester, Second

Keywords

second trimester, pregnancy termination, misoprostol, foley bulb

Brief summary

The purpose of this study is to compare two methods of pregnancy termination on the time to delivery in the second trimester.

Detailed description

Medical termination in the second trimester is performed for many indications. Successful termination is dependant on ripening of the cervix prior to labor induction. Multiple methods of cervical ripening and labor induction have been used for pregnancy termination in the second trimester. These two methods have different mechanisms of action. This study seeks to evaluate the effectiveness of these two methods.

Interventions

DEVICEFoley bulb

DRUGmisoprostol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

14 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* indication for pregnancy termination, gestational age from 13-27 weeks

Exclusion criteria

* multiple gestation, previous uterine surgery, rupture of membranes, latex allergy

Design outcomes

Primary

Measure	Time frame
Time to vaginal delivery	—

Secondary

Measure	Time frame
Rate of chorioamnionitis	—
Rate of maternal fever	—
Rate of postpartum hemorrhage	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026