Plasma Brain Natriuretic Peptide Levels in Pregnancy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00324402

Enrollment

Registered

2006-05-11

Start date

2006-08-31

Completion date

2008-06-30

Last updated

2020-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiomyopathy, Pregnancy

Keywords

brain natriuretic peptide, pregnancy, biomarker

Brief summary

To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.

Detailed description

The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* women age 18 to 40 * second trimester of pregnancy

Exclusion criteria

* known cardiac or valvular disease, * atrial fibrillation or other arrhythmia, * pulmonary hypertension, * chronic hypertension, * hypertensive disorders of pregnancy, * morbid obesity (BMI \> 40 kg/meter squared) * history of sleep apnea * multiple gestation * known renal dysfunction * medications known to affect cardiac function * current or past abnormal echocardiogram

Countries

United States

Outcome results