Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone

RIRS - A Method of Treating the ESWL Resistant Kidney Stone

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00323843

Enrollment

Registered

2006-05-10

Start date

2006-06-30

Completion date

2007-02-28

Last updated

2007-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Stone, Ureteroscopy

Keywords

Kidney stone, ureteropyeloscopy, renal pelvic pressure

Brief summary

Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management of kidney stone by topical administration of drugs? In order to secure fewer complications in ureteroscopic operations the pharmacological agent isoproterenol is tested on pigs and human to determine its potential of lowering intrarenal pressure.

Interventions

DRUGIsoproterenol

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Indication for RIRS procedure * Age \> 18 years * Normotensive * Capable of understanding information given

Exclusion criteria

* Previous myocardiac infarct * Daily use of alpha- og beta- blocking medicine og calcium antagonists * Use of NSAID the last 2 days * Stone in the ureter * Declared * Known malignant disease in urinary tract * Bladder disease * Nephrostomies inserted * JJ-catheters inserted * Prisoners * Pregnant * Nursing mothers

Design outcomes

Primary

Measure	Time frame
Renal pelvic pressure	—

Secondary

Measure	Time frame
Blood pressure	—
Pulse	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026