A Study of the Effect on Oro-dental Complications of Intensity Modulated Radiotherapy (IMRT) Versus Conventional Radiotherapy in Patients With Cancer of the Head or Neck

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00323466

Enrollment

Registered

2006-05-09

Start date

2007-05-31

Completion date

2008-02-29

Last updated

2023-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer: Head or Neck

Brief summary

Study to investigate the effect of two types of radiotherapy on saliva: IMRT versus conventional radiotherapy. In each group, one part will receive normal dental preventive treatment. The other part will use products for treatment of dry mouth (Biotene gamma). Both anorganic and organic components of the saliva will be studied at different time points, combined with bacterial swabs.

Interventions

PROCEDUREIMRT versus conventional radiotherapy

Comparing MRT versus conventional radiotherapy

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* \> 18 years old * Cancer of head or neck

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Volume of saliva	Before, during (week 4) and after radiation (week 2, 3, 6 and 12)
Quality of saliva	Before, during (week 4) and after radiation (week 2, 3, 6 and 12)
Oral flora	Before, during (week 4) and after radiation (week 2, 3, 6 and 12)

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026