Acute Renal Failure, Dialysis
Conditions
Brief summary
The goal of the present study is the comparison of different dialysis strategies in critically ill patients with acute renal failure on the intensive care unit. Patients are treated with either continuous dialysis or hemofiltration. Outcome measures are death, restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.
Detailed description
The goal of the present study is the comparison of different renal replacement strategies in critically ill patients with acute renal failure on the intensive care unit. In a prospectively randomized clinical study patients are treated with either continuous dialysis (SLED) or continuous hemofiltration (CVVHD). 200 patients should be included in the study (n=100 each). The primary outcome is death at ICU, secondary outcome measures are restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.
Interventions
PROCEDURERenal replacement therapy
ICU patients with acute renal failure were prospectively randomized to either CVVHD or SLED
Sponsors
Heidelberg University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients 18 years or older * Written informed consent * No pre-existing dialysis dependency
Exclusion criteria
* Minors / children * No consent * Severe electrolyte disturbances which necessitates special dialysis therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death | 90 days |
Secondary
| Measure | Time frame |
|---|---|
| Restitution of renal function | 90 days |
| days on ICU | in hospital |
| hemodynamic stability | in hospital |
| dialysis efficiency | in hospital |
| costs | in hospital |
Countries
Germany
Outcome results
None listed