Computer-Based Therapy for Mild Cognitive Impairment

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00319943

Enrollment

Registered

2006-04-27

Start date

2004-09-30

Completion date

2006-07-31

Last updated

2006-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment

Keywords

Cognitive remediation, Cognitive impairment, computer, training

Brief summary

The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).

Detailed description

The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.

Interventions

PROCEDUREComputer-based training for Mild Cognitive Impairment (MCI)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

65 Years to 90 Years

Healthy volunteers

Inclusion criteria

1)65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function. 3)Fluency in English 4)Willing to meet the time commitment of the study \-

Exclusion criteria

1. Clinically significant cerebrovascular disease 2. Individuals scheduled to begin acetylcholinesterase inhibitor (AChEI) therapy -

Design outcomes

Primary

Measure	Time frame
The study investigates changes in a neuropsychological assessment battery pre-randomization	—
and upon the completion of training.	—

Secondary

Measure	Time frame
Early evaluations will be conducted from brain imaging; specifically, date	—
obtained via positron emission tomography (PET), magnetoencephalography (MEG),	—
electroencephalography (EEG), and functional magnetic resonance imaging (fMRI)	—
studies.	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026