Anemia, Coronary Artery Bypass Surgery
Conditions
Keywords
Postoperative care, Cardiac Surgery, Blood Transfusion
Brief summary
The purpose of this study is to determine whether a less restrictive strategy of red blood cell transfusion in elderly patients following coronary bypass surgery results in enhanced postoperative recovery as determined by quality of life assessment, exercise tolerance and clinical outcomes. Two postoperative transfusion strategies: 1. Liberal - transfused when Hgb is \<100g/L 2. Restrictive - transfused when Hgb is \<70g/L
Interventions
PROCEDUREBlood Transfusion
Blood transfusion will be administered when the transfusion trigger is met.
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
70 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients \>=70 years of age undergoing non-emergency coronary artery bypass surgery * Initial postoperative hemoglobin level 70-90g/L
Exclusion criteria
* Patients who are unable to provide informed consent in English * Patients with preoperative hemoglobin concentrations \<100g/L * Patients who require emergency re-operation * Patients with intraoperative or postoperative bleeding diathesis * Patients with postoperative clinical instability (eg. low output state) * Patients in whom insertion of an intra-aortic balloon pump is required
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Distance walked during 6 minute walk test at 5 weeks postop | 5 weeks |
Secondary
| Measure | Time frame |
|---|---|
| renal failure, hospital length of stay, Quality of Life questionnaire | during hospital stay |
Countries
Canada
Outcome results
None listed