Cambridge Anti-Myopia Trial: Accommodation Training and Aberration Control in Myopia Development

Accommodation Training and Aberration Control in Myopia Development

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00317551

Enrollment

200

Registered

2006-04-25

Start date

2005-04-30

Completion date

Unknown

Last updated

2006-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia

Keywords

Aberration control, Accommodative facility, Accommodative response, Peripheral refraction, Accommodative convergence to accommodation ratio

Brief summary

We have identified focussing problems related to myopia getting worse. Our trial uses optical and orthoptic interventions that correct the focussing problems to see if this retards myopia progression.

Detailed description

Myopia is a burgeoning health and social problem. Currently there is no acceptable clinical treatment that prevents progression. This study is a double masked placebo controlled block randomized clinical trial of two interventions, to treat accommodative factors we have identified as being significantly correlated to myopia progression (rather than to the presence of myopia). We have shown that the interventions normalise the accommodative factors, and this trial examines the effect of these interventions on myopia progression.

Interventions

DEVICEAberration controlled contact lens

BEHAVIORALVision training

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

14 Years to 21 Years

Healthy volunteers

Yes

Inclusion criteria

* Best corrected visual acuity of 6/5 in each eye * Myopia in each meridian of at least 0.50 D * Willingness to give consent * Willingness to undertake any treatment option

Exclusion criteria

* History of systemic/ocular pathology * History of any ocular surgery * More than 10D of myopia * Astigmatism more than 1.00 D

Design outcomes

Primary

Measure	Time frame
Age effects on refractive changes over 2 years	—
Change in refractive error in myopia in 6 monthly intervals for 2 years	—
Change in axial length in 6 monthly intervals for 2 years	—

Secondary

Measure	Time frame
Change in accommodative response in 6 monthly intervals for 2 years	—
Change in AC/A ratio in 6 monthly intervals for 2 years	—
Change in accommodative facility in 6 monthly intervals for 2 years	—
Change in peripheral refraction in 6 monthly intervals for 2 years	—

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026