Critical Illness, Kidney Failure, Acute
Conditions
Keywords
Kidney failure, Acute, Genetic Polymorphism, Angiotensin-converting enzyme
Brief summary
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.
Detailed description
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.
Interventions
PROCEDUREBlood sampling for PCR
Sponsors
University Hospital, Caen
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 yrs * ICU stay \> 48 hours
Exclusion criteria
* Age \< 18 yrs * Creatinine \> 180 µmol/L * Absence of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of ARF | During ICU stay |
Secondary
| Measure | Time frame |
|---|---|
| Mortality | ICU and Hospital mortality |
Countries
France
Outcome results
None listed