Pulmonary Diffusing Capacity
Conditions
Keywords
Diffusion, Membrane diffusing capacity, Alveolar capillary gas diffusion, Transfer factor, Nitric oxide diffusion
Brief summary
Using a rapidly responding nitric oxide analyzer in a new developed modular lung-function-setup we are going to measure steady-state NO diffusing capacity in 107 healthy subjects (age 6-45 years). The results will be compared to those measured by using carbon monoxide single-breath estimates. We like to show that the new method is sufficient to measure exactly lung diffusion capacity in this collective.
Interventions
DRUGNitric oxide, Carbon monoxide, Helium
Sponsors
University Hospital Tuebingen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Lung function testing possible * Written consent
Exclusion criteria
* Pulmonary, neuromuscular, cardiovascular, endocrinological illness * Pregnancy * Abuse of nicotine, alcohol, drugs during the last two years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TLNOss | — |
| TLCOsb | — |
Secondary
| Measure | Time frame |
|---|---|
| functional residual capacity | — |
| airway resistance | — |
| lung clearance index | — |
| Breathing frequency | — |
| vital capacity | — |
| total lung capacity | — |
| forced expiratory volume in one second | — |
| tidal volume | — |
Countries
Germany
Contacts
Primary ContactTobias Pantalitschka, MD
Outcome results
None listed