Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

Placebo-Controlled Randomized Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Dysfunctional Labor

Status

Withdrawn

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00315913

Enrollment

Registered

2006-04-19

Start date

2004-01-31

Completion date

2008-03-31

Last updated

2019-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysfunctional Labor

Keywords

Labor, Dysfunctional Labor, Labor Arrest, Primary Cesarean Section Prevention

Brief summary

The purpose of this study is to determine whether propranolol is better than oxytocin for the treatment of labor abnormalities. The endpoint is the rate of vaginal delivery experienced by women receiving prolonged oxytocin versus propranolol.

Detailed description

This trial was designed to test if propranolo can reduce the c section rate for dysfuctional labor. Due to stringent inclution and exclusion criteria and low enrollment the study was closed.

Interventions

DRUGPropranolol

IV Propranolol 1mg/min for a total of 2 minutes. Total dose 2mg

OTHERIV Placebo

IV Saline Solution

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Must be term pregnancy (\> 37 weeks) * Vertex presentation * Active labor (4-5 centimeters dilated)

Exclusion criteria

* Heart disease * Diabetes * Currently taking propranolol * Contraindications to labor or vaginal delivery * Multiple gestations * Preterm * Chorioamnionitis

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026