Prophylactic Effect of Memantine in Chronic Tension-Type Headache

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00315666

Enrollment

Registered

2006-04-19

Start date

2006-05-31

Completion date

2007-06-30

Last updated

2009-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tension-Type Headache

Keywords

Chronic tension-type headache

Brief summary

The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.

Interventions

DRUGmemantine

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Chronic tension-type headache * Normal urine pH

Exclusion criteria

* More than 1 migraine attack/month * Other major illnesses * Overuse of medicine/alcohol * Women not using AC * Pregnant/breast-feeding women * Allergy to memantine

Design outcomes

Primary

Measure	Time frame
Headache duration	—
Headache intensity	—

Secondary

Measure	Time frame
Headache frequency	—
The use of simple analgesics	—
Side effects	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026