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Anecortave Acetate for Treatment of Steroid Induced Intraocular Pressure (IOP) Elevation

A Study of the Safety and Efficacy of Anecortave Acetate for Treatment of Steroid Induced Intraocular Pressure (IOP) Elevation

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00315640
Enrollment
70
Registered
2006-04-19
Start date
2005-12-31
Completion date
2009-07-31
Last updated
2012-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases

Keywords

Elevated IOP due to intravitreal triamcinolone therapy

Brief summary

The purpose of this study is to evaluate the safety and efficacy of anecortave acetate depot when administered for the treatment of elevated IOP following treatment with steroids.

Interventions

DRUGAnecortave Acetate Sterile Suspension, 6 mg/mL

One 0.5 mL anterior juxtascleral depot (AJD) injection in the study eye

DRUGAnecortave Acetate Suspension Depot, 30 mg/mL

One 0.5 mL anterior juxtascleral depot (AJD) injection in the study eye

DRUGAnecortave Acetate Sterile Suspension, 60 mg/mL

One 0.5 mL anterior juxtascleral depot (AJD) injection in the study eye

OTHERAnecortave Acetate Vehicle

One 0.5 mL anterior juxtascleral depot (AJD) injection in the study eye

Sponsors

Alcon Research
Lead SponsorINDUSTRY

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Either gender * 18 years of age or older * IOP elevation caused by steroid usage * Other protocol-defined inclusion criteria may apply

Exclusion criteria

* Under 18 years of age * Other protocol-defined

Design outcomes

Primary

MeasureTime frame
Mean change in IOP at Week 4 from BaselineWeek 4

Countries

Brazil, Hungary, Italy, Netherlands, Puerto Rico, Spain, United Kingdom, United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026