Irritable Bowel Syndrome
Conditions
Keywords
Diet, Fiber, Irritable Bowel Syndrome, Colonic Flora
Brief summary
Despite there being no clearcut advantages, one of the most common recommendations in IBS management is to increase the amount of dietary fibres. In some IBS patients fibres have a deleterious effect on pain and bloating. It has been shown that butyrate can increase colonic sensitivity in rats. Our purpose is to study whether butyrogenic fibres can modify rectal sensitivity and symptoms in IBS and healthy control through a modification of colonic flora.
Detailed description
Despite there being no clearcut advantages, one of the most common recommendations in IBS management is to increase the amount of dietary fibres. In some IBS patients fibres have a deleterious effect on pain and bloating. It has been shown that butyrate can increase colonic sensitivity in rats. Our purpose is to study whether butyrogenic fibres can modify rectal sensitivity and symptoms in IBS and healthy control through a modification of colonic flora.
Interventions
DRUGDiet
Sponsors
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
EA 3848 UdA
ERT: Clinical Trial Technology Solutions
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Female aged 18-60 years * Normal volunteers and patients with IBS assessed by Rome II criteria * Effective contraception * Affiliated to National Health Service * Having received oral and written information about the study * Having provided her written informed consent
Exclusion criteria
* Significant clinical or biological abnormality * Organic gastrointestinal disease * Subjects having lower than 15g/day or higher than 20g/day fibres intake * Antibiotic treatment during the month preceding the pre inclusion day * Antispasmodics, antidiarrheics, laxatives, and prokinetics during the week preceding the pre inclusion day and during all the study period. * Digestive surgery tract except appendectomy and cholecystectomy * Alcohol abuse * Drug addiction * Major psychiatric disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discomfort threshold to rectal distension | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal discomfort (questionnaire) | — |
| Quality of life (questionnaire) | — |
| Rectal sensitivity : first sensation and threshold for first sensation of the need to defecate. | — |
| Functional composition of colonic flora | — |
| Fermentation profile of ingested fibre | — |
| Taxonomic composition of colonic flora | — |
Countries
France
Contacts
Primary ContactMichel Dapoigny, Pr
Outcome results
None listed