Multiple Myeloma and Plasma Cell Neoplasm
Conditions
Keywords
stage I multiple myeloma, stage II multiple myeloma, stage III multiple myeloma, refractory multiple myeloma
Brief summary
RATIONALE: Giving chemotherapy, such as melphalan and busulfan, before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving tacrolimus and methotrexate before or after transplant may stop this from happening. PURPOSE: This phase II trial is studying how well giving melphalan together with busulfan followed by donor peripheral stem cell transplant, tacrolimus, and methotrexate works in treating patients with multiple myeloma.
Detailed description
OBJECTIVES: Primary * Evaluate transplant-related mortality in patients with multiple myeloma treated with a myeloablative conditioning regimen comprising melphalan and busulfan followed by HLA-matched, allogeneic peripheral blood stem cell transplantation (PBSCT) and graft-vs-host disease prophylaxis with tacrolimus and methotrexate. Secondary * Determine the disease response in patients treated with this regimen. * Determine the 1-year progression-free survival and overall survival in patients treated with this regimen. OUTLINE: * Conditioning regimen: Patients receive melphalan IV over 30 minutes on day -6 and busulfan IV over 3 hours on days -5 to -3. * Peripheral blood stem cell transplantation (PBSCT): Patients undergo HLA-matched, related donor, allogeneic PBSCT on day 0. * Graft-versus-host disease (GVHD) prophylaxis: Patients receive tacrolimus IV continuously or orally twice daily beginning on day -2 and continuing until day 80 followed by a taper until day 180 in the absence of GVHD or disease progression. Patients also receive methotrexate IV on days 1, 3, 6, and 11. After completion of study treatment, patients are followed every 6 months for 2 years and then annually thereafter. PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
Interventions
DRUGbusulfan
DRUGmelphalan
DRUGmethotrexate
DRUGtacrolimus
PROCEDUREallogeneic hematopoietic stem cell transplantation
PROCEDUREperipheral blood stem cell transplantation
Sponsors
National Cancer Institute (NCI)
Fred Hutchinson Cancer Center
Study design
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of multiple myeloma * Stage I disease with disease progression during the second of ≥ 2 lines of prior therapy * Stage II or III disease, meeting 1 of the following criteria: * Failed to achieve at least a partial response after ≥ 2 courses of prior therapy * Progressive disease after ≥ 2 courses of prior therapy * Presented with high-risk features at diagnosis, including any of the following: * Cytogenetic abnormality * Del 13 or 4,14 by fluorescent in situ hybridization (FISH) * Elevated lactic dehydrogenase * Beta 2 microglobulin \> 5.5 * Circulating peripheral blood plasma cells * Any stage disease with disease progression \> 6 months after prior autologous stem cell transplantation * Availability of an HLA-matched, related donor between 12 and 75 years of age\* * No bone marrow donors NOTE: \*Donors \> 75 years of age are eligible at the discretion of the principal investigator PATIENT CHARACTERISTICS: * Karnofsky performance status 70-100% * Creatinine clearance \> 60 mL/min * Bilirubin ≤ 2.5 mg/dL * ALT/AST \< 2 times upper limit of normal * Cardiac ejection fraction ≥ 49% * DLCO ≥ 50% corrected * FEV\_1 ≥ 60% * Not pregnant or nursing * Fertile patients must use effective contraception * HIV negative * No cirrhosis * No chronic inflammatory or fibrotic liver disease PRIOR CONCURRENT THERAPY: * See Disease Characteristics * At least 6 months since prior autologous transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transplant-related mortality at 180 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease response (complete response) | — |
| Progression-free survival | — |
| Overall survival at 1 year | — |
Countries
United States
Outcome results
None listed