Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease or Hypertension

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00313430

Enrollment

Registered

2006-04-12

Start date

2004-05-31

Completion date

Unknown

Last updated

2015-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension, Renal Insufficiency, Chronic

Keywords

Urine concentration ability, chronic renal insufficiency, hypertension, aquaporin2, Patients with chronic renal insufficiency, Patients with hypertension, Healthy volunteers

Brief summary

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients with chronic renal insufficiency, aged between 18 and 65, both men and women * Creatinine clearance between 30-59 ml/min * Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg. * Healthy volunteers, aged between 18 and 65, both men and women

Exclusion criteria

* Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs * Cancer * Alcohol abuse * Medicine abuse * Pregnancy

Countries

Denmark

Outcome results