A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00311389

Enrollment

408

Registered

2006-04-06

Start date

2003-01-31

Completion date

2004-09-30

Last updated

2012-02-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Open-angle, Ocular Hypertension

Keywords

Glaucoma, POAG, OAG, OHT

Brief summary

The purpose of this study is to evaluate the intraocular pressure(IOP)-lowering efficacy of a combination IOP-lowering therapy in patients with open-angle glaucoma or ocular hypertension.

Interventions

DRUGTravoprost 0.004%/Timolol maleate 0.5% ophthalmic solution

Investigational ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension

DRUGLatanoprost 0.005%/Timolol 0.005% ophthalmic solution

Commercially marketed ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- As specified in protocol

Exclusion criteria

\- As specified in protocol

Design outcomes

Primary

Measure	Time frame
Mean Intraocular Pressure (IOP)	12 months

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026