Colorectal Neoplasms
Conditions
Keywords
dendritic cells, antigens, neoplasm
Brief summary
Dendritic cells loaded with tumor antigens induce cytotoxic T-cells which have been proved capable of killing both melanoma and breast cancer cells. Melanoma and colorectal cancer cells express some common antigens. Hence it is possible to use melanoma lysate to load the dendritic cells with tumor antigens similar to the antigens expressed by the patients' colorectal cancer cells. The patient receives 10 vaccinations with 14 days between each. The parameters for effect are changes in tumor/metastasis size measured with computed tomography (CT), decrease in serum concentration of carcinoembryonic antigen (CEA), performance status measured by the World Health Organization (WHO) criteria, and Quality of Life.
Interventions
BIOLOGICALMelCancerVac
Sponsors
University Hospital, Gentofte, Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Verified cancer of colon or rectum * No chemo- or radiation therapy in 6 weeks * Performance status 0, 1, or 2 (WHO criteria) * Adequate function of the kidneys, liver, lungs, and heart * Adequate function of the hematopoietic system and the coagulation system * Negative pregnancy test and adequate birth control for fertile women
Exclusion criteria
* Pregnancy * Uncontrolled infection
Countries
Denmark
Outcome results
None listed