Inflammatory Stress, Myocardial Ischaemia, Oxidative Stress
Conditions
Brief summary
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
Detailed description
Laparoscopic gall bladder surgery is connected with changes in the body resulting in cell damage and inflammation. Melatonin is a hormone produced in brain and regulate sleep rhythm, temperature, production of other hormones and function of organs. Furthermore melatonin can modify cell damage and inflammation. After surgery the production of melatonin is disturbed. The purpose of this study is therefore to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
Interventions
DRUGMelatonin (drug)
DRUGLaktose
Sponsors
University Hospital, Gentofte, Copenhagen
Study design
Time perspective
OTHER
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* indikation for laparoscopic cholecystectomy * women between 18 and 70 years old
Exclusion criteria
* men * acute cholecystectomy * pancreatitis * renal insufficient * well-known liver insufficient * cardiovascular disease (arrhythmia, well-known ischaemic heart disease) * drug therapy (digoxin, Ca-antagonist, amiodaron, beta-blocker) * anticoagulation therapy (marevan and marcoumar) * praeoperative therapy with opioid, anxiolytica and hypnotica) * well-known sleep disease * endocrine disease in drug therapy (diabetes mellitus, thyroid disease) * daily alcohol consumption (more than 5 drinks) * bad compliance (language difficulty, mental problems etc.) * pregnancy and breast-feeding * lack of written consent
Countries
Denmark
Contacts
Primary ContactBülent Kücükakin
Outcome results
None listed