Study of Sildenafil in Patient With Heart Failure.

Measurement of the Effect of Sildenafil Citrate (Viagra) on the Hemodynamics of Exercise Tolerance in Advanced Congestive Heart Failure.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00309816

Enrollment

Registered

2006-04-03

Start date

2001-12-31

Completion date

2006-02-28

Last updated

2006-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congestive Heart Failure

Keywords

Exercise stress test

Brief summary

The purpose of this study is to determine if sildenafil (Viagra) improves exercise tolerance.

Detailed description

Patients will undergo an exercise stress test. One dose of Sildenafil will then be given, followed by a one hour rest period. A repeat exercise stress test will then be repeated.

Interventions

DRUGsildenafil

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

Age 18 - 75 Ejection fraction \<35% Heart failure limited by fatigue and shortness of breath -

Exclusion criteria

Inability to exercise. Patients with shortness of breath while resting. Patient requiring intravenous medication. Patients taking the following medications: nitroglycerine pill/patch/paste, isordil and Imdur \-

Design outcomes

Primary

Measure	Time frame
Patients will have exercise capacity measured by an exercise stress test before and after one dose of sildenafil.	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026