Tuberculosis
Conditions
Keywords
tuberculosis, tuberculin, childhood, pain
Brief summary
The use of local anaesthesia efficiently reduces pain due to needle puncture. However, when tuberculin skin test is performed it is the skin reaction to tuberculin injection that is studied. It is a quantitative skin reaction measured in millimiters. From the study of literature it is not known whether local anaesthetic modify skin reaction to tuberculin. Therefore, before recommending the use local anaesthesia for tuberculin intradermal injection we have to rule out a potential effect of local anaesthetic on the result of the test. This is particularly important in children, since there are more sensitive to pain than adults
Interventions
DRUGlidocaine / Prilocaine
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
1 Months to 15 Years
Healthy volunteers
No
Inclusion criteria
hospitalized or non hospitalized infant or child (3 months-15 years)requiring a tuberculin skin test, in our hospital. hospitalized 1 to 3 months old infants requiring a tuberculin skin test, in our hospital. \-
Exclusion criteria
* child with contra indication to the use of Lidocaine / prilocaine * child with evolutive dermatitis on forearms * premature or newborn (less than 1 month of age) * infants (1 - 24 months of age)who has yet received repeated local anaesthesia (at least 2)during the 24 previous hours * infants (1 - 24 months of age)who is treated with a drug that could enhance the risk of methhaemoglobinemia * child with previous evere local reaction to tuberculin injection (necrosis,ulceration) * child with history of tuberculosis disease * child with hepatic failure * parents or the child himself if lod enough, have not given their agreement for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of tuberculin skin tests reaction performed with and without | — |
| local anaesthesia, in a child (intra subject reproducibility) | — |
Secondary
| Measure | Time frame |
|---|---|
| pain evaluation in child over 5 years of age between tuberculin skin tests performed with and without local anaesthesia | — |
| influence of local anaesthesia use, on tuberculin skin test interpretation | — |
| local tolerance to lidocaine / prilocaine | — |
| relationship between local anaesthesia use and failure to perform a correct intradermal injection | — |
| between observer reproducibility | — |
Countries
France
Contacts
Primary ContactNicole Beydon, MD
Backup ContactEstelle Marcault, ARC
Outcome results
None listed