Obstructive Sleep Apnea
Conditions
Brief summary
AutoCPAP would lead to better compliance than FixCPAP
Detailed description
A prospective, randomized crossover cohort. Study subjects consisted of patients newly diagnosed with obstructive sleep apnea (OSA) confirmed with sleep study. All are CPAP naïve. Randomization: Arm 1: auto CPAP sleep study then auto CPAP for 2 months Arm 2: fixed CPAP titration then fixed CPAP for 2 months Then switch over to the other arm Trial end after 4 months, compliance and other parameters would be compared between two arms as described in the endpoint session.
Interventions
DEVICEAutoCPAP
DEVICEFixCPAP
Sponsors
Chinese University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All subjects should be CPAP naïve. * OSA confirmed with sleep study * Presence of daytime symptoms with excessive daytime sleepiness * Age between 18 to 65 * RDI greater than 30 * Agreed to participate in trial with informed consent signed
Exclusion criteria
* Patients not suitable to nasal CPAP because of facial abnormality leading to poor mask fitting. * Patients with known COPD with type II failure * Patients with known heart failure. * Patients with predominant central sleep apnea. * Patients need bilevel positive airway pressure ventilation. * Patients refusing to participate the trial. * Patients have difficulty to follow up regularly. * patients with untreated or under treatment of hypothyroidism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the compliance of auto-CPAP and fixed CPAP in terms of CPAP usage hours. | — |
| To compare the clinical efficacy of auto-CPAP and fixed CPAP in terms of pressure level to abolish OSA, Epworth sleepiness scale and quality of life questionnaire. | — |
| To compare patient acceptance of the different type of treatment. | — |
Countries
China
Outcome results
None listed