Fecal Bacterial Flora in Clostridium Difficile-Associated Diarrhea

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00304876

Enrollment

Registered

2006-03-20

Start date

2005-10-31

Completion date

2007-01-31

Last updated

2010-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic-Associated Colitis, Enterocolitis, Pseudomembranous Colitis

Keywords

Clostridium difficile associated diarrhea

Brief summary

The investigators propose to study intensively the bacteriology of feces in C. difficile associated diarrheal disease, using a variety of conventional and very up-to-date techniques.

Detailed description

Clostridium difficile associated colitis is an increasing problem in hospitals throughout the developed world; the number of cases has increased, and the failure to respond to conventional therapy has become far more common. The investigators have recently documented in the medical literature (Clin Infect Dis, June, 2005; Lancet Infect Dis, August, 2005). Possible reasons for failure of treatment include persistence of C. difficile and/or imbalance of other bacterial flora in the colon. The bacteriology of fecal flora in C. difficile associated diarrhea has not been studied.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with antibiotic-associated diarrhea with a positive assay for C. difficile toxin * Patients with antibiotic-associated diarrhea with 3 negative assays for C. difficile toxin * Patients with antibiotic-associated diarrhea that has failed to respond to conventional therapy * Hospitalized patients who have received \>2 antibiotics and who have no symptoms of diarrhea or abdominal discomfort

Exclusion criteria

* none

Countries

United States

Outcome results