Alcoholism
Conditions
Keywords
Alcoholism, Emotion, Cognition, Brain scans
Brief summary
The purpose of this study is to determine whether long-term chronic alcoholism is associated with changes in emotional functioning and brain structure and function.
Detailed description
This research investigates brain structure and function in alcoholics compared to healthy nonalcoholic individuals. Alcoholics have shown impairments in cognitive processing of emotional signals. Some alcoholics are impaired in social skills, and many are unable to implement the strategies for interpersonal interactions that they recommend for themselves. For example, alcoholics have difficulty interpreting non-verbal emotional cues and recognizing facial expressions of emotion. When listening to sentences, alcoholics also have some difficulty judging emotional intonations and emotional content. In our research, we are trying to understand where in the brain these emotional behaviors take place, and whether or not the brain functions differently for alcoholic and nonalcoholic individuals. We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
Interventions
PROCEDUREMagnetic Resonance Imaging (MRI)
We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
BEHAVIORALInterviews, cognitive tests, and emotional measurements
We present emotional words and pictures on a computer screen, and using MRI scans, we observe how the brain works when people purposefully respond to the words and pictures. Additionally, we are comparing brain structure and activation patterns in men and women, because there may be gender differences in responses to emotional stimuli.
Sponsors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
US Department of Veterans Affairs
Boston University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
25 Years to 76 Years
Healthy volunteers
Yes
Inclusion criteria
* Male and female right-handed people 25 years of age or older. * Participants either will have a past Diagnostic and Statistical Manual version IV (DSM-IV) diagnosis of alcohol dependence, or no such history at all. * Participants will have signed an informed consent.
Exclusion criteria
* Pregnant women. * Shrapnel or other metal in body (dental fillings OK)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alcoholism's effects on thinking, behavior and brain functioning | several visits over approximately one month |
Countries
United States
Outcome results
None listed