Effect of Folic Acid Treatment in Coronary Artery Disease

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00300352

Enrollment

Registered

2006-03-08

Start date

2004-05-31

Completion date

Unknown

Last updated

2008-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Coronary artery disease, Folic acid, Endothelial function

Brief summary

We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function

Detailed description

Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease.

Interventions

DRUGFolic Acid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Clinical diagnosis of coronary artery disease

Exclusion criteria

Recent acute coronary event Renal and/or hepatic dysfunction Metallic implants

Design outcomes

Primary

Measure	Time frame
Improvement in noninvasive measures of vascular function	—

Secondary

Measure	Time frame
Improvement in laboratory measures of vascular function	—

Countries

United Kingdom

Contacts

Primary ContactCheerag C Shirodaria, MB BS MRCP

cheerag.shirodaria@cardiov.ox.ac.uk+(44)1865-221866

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026