Patients With Liver Metastases From Colorectal Cancer
Conditions
Brief summary
This study tests the feasibility and reproducibility of patient-specific motion models. These will be used for quantification of safe margin reduction. Patient-specific motion models will be built by post-processing 4D MRI data with non-rigid registration. By comparing these models between visits, model reproducibility will be assessed, and the methodology refined.
Detailed description
The study will use a real time position management (RPM) system for respiratory gating. The RPM system senses the respiration motion of the patient by tracking a pair of reflective markers on a lightweight marker block constructed of a synthetic material. This block is placed on the patient's abdomen. During Radiotherapy, the beam is only switched on at pre-determined phases of respiration. The appropriate phase of respiration is determined by the RPM system. This implies a reliable correlation of external block motion to internal hepatic movement. This correlation is not a simple one, and requires modeling.
Interventions
None listed
Sponsors
Royal Marsden NHS Foundation Trust
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Histologically confirmed adenocarcinoma compatible with primary disease in the colon or rectum * Aged 18 years or older * Unequivocal contrast-enhanced CT and/or MRI evidence of malignant single or multiple metastases in the liver, metastases at other sites will not be an exclusion criterion * WHO performance status 0-2 and life expectancy of at least 12 weeks * Informed written consent
Exclusion criteria
* Pregnancy or breast feeding * Evidence of ascites * Patients unable for whatever reason to lie flat * Patients unable to give fully informed consent * Age\< 18 years
Countries
United Kingdom
Outcome results
None listed